From Wikipedia, the free encyclopedia
In enzymology, a 1-alkyl-2-acetylglycerophosphocholine esterase (EC 220.127.116.11) is an enzyme that catalyzes the chemical reaction
- 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O 1-alkyl-sn-glycero-3-phosphocholine + acetate
Thus, the two substrates of this enzyme are 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine and H2O, whereas its two products are 1-alkyl-sn-glycero-3-phosphocholine and acetate.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase. Other names in common use include 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, and alkylacetyl-GPC:acetylhydrolase. This enzyme participates in ether lipid metabolism.
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1BWP, 1BWQ, 1BWR, 1ES9, 1FXW, 1VYH, and 1WAB.
- Blank ML, Lee T, Fitzgerald V, Snyder F (1981). [Expression error: Missing operand for > "A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid)"]. J. Biol. Chem. 256: 175–8. PMID 7451433.