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albumin (n.)
1.a simple water-soluble protein found in many animal tissues and liquids
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Merriam Webster
AlbuminAl*bu"min (�), n. (Chem.) A thick, viscous nitrogenous substance, which is the chief and characteristic constituent of white of eggs and of the serum of blood, and is found in other animal substances, both fluid and solid, also in many plants. It is soluble in water and is coagulated by heat and by certain chemical reagents.
Acid albumin, a modification of albumin produced by the action of dilute acids. It is not coagulated by heat. -- Alkali albumin, albumin as modified by the action of alkaline substances; -- called also albuminate.
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albumin (n.)
Voir aussi
albumin (n.)
⇨ (131)I-Macroaggregated Albumin • 99mTc-Human Serum Albumin • Abnormality of albumin • Albumin Proximal Factor • Albumin Receptor • Albumin Receptors • Plasma Albumin • Receptors, Albumin • Serum Albumin • Serum Albumin, Bovine • Serum Albumin, Radio-Iodinated • Serum Albumin, Radioiodinated • Tc 99m-Albumin • Tc 99m-Albumin Colloid • Tc99m-Albumin • Technetium-99m Albumin Colloid • serum albumin
⇨ Albumin human • Albumin iodinated i-125 serum • Albumin iodinated i-131 serum • Albumin photograph • Albumin tannate • Bovine serum albumin • CSF albumin • CSF/serum albumin ratio • Egg albumin • Human serum albumin • Iodinated albumin • Iodinated i-125 albumin • Radioiodinated serum albumin • Serum albumin • Serum-ascites albumin gradient • Single Pass Albumin Dialysis • Surfactant-albumin ratio • Technetium tc-99m albumin aggregated
Wikipedia
This article needs additional citations for verification. (March 2009) |
Serum albumin family | |||||||||
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Structure serum albumin.[1][2] | |||||||||
Identifiers | |||||||||
Symbol | Serum_albumin | ||||||||
Pfam | PF00273 | ||||||||
Pfam clan | CL0282 | ||||||||
InterPro | IPR014760 | ||||||||
SMART | SM00103 | ||||||||
PROSITE | PS51438 | ||||||||
SCOP | 1ao6 | ||||||||
SUPERFAMILY | 1ao6 | ||||||||
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Albumin (formed from Latin: albumen[3] '(egg) white; dried egg white') refers generally to any protein that is water soluble, is moderately soluble in concentrated salt solutions, and experiences heat denaturation. Albumins are commonly found in blood plasma, and are unique from other blood proteins in that they are not glycosylated. Substances containing albumin, such as egg white, are called albuminoids.
A number of blood transport proteins are evolutionarily related, including serum albumin, alpha-fetoprotein, vitamin D-binding protein and afamin.[4][5][6]
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For patients with low blood volume, there is no evidence that albumin reduces mortality when compared with cheaper alternatives such as normal saline, or that albumin reduces mortality in patients with burns and low albumin levels. Therefore, the Cochrane Collaboration recommends that it not be used, except in clinical trials.[7]
Albumin is the main protein of plasma; it binds water, cations (such as Ca2+, Na+ and K+), fatty acids, hormones, bilirubin, thyroxine (T4) and drugs (including barbiturates) - its main function is to regulate the colloidal osmotic pressure of blood. Alpha-fetoprotein (alpha-fetoglobulin) is a fetal plasma protein that binds various cations, fatty acids and bilirubin. Vitamin D-binding protein binds to vitamin D and its metabolites, as well as to fatty acids. The biological role of afamin (alpha-albumin) has not yet been characterised.[citation needed]
The 3D structure of human serum albumin has been determined by X-ray crystallography to a resolution of 2.5 Å.[8]
Albumin comprises three homologous domains that assemble to form a heart-shaped molecule.[2] Each domain is a product of two subdomains that possess common structural motifs.[2] The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. Structurally, the serum albumins are similar, each domain containing five or six internal disulfide bonds, as shown schematically below:
+---+ +----+ +-----+ | | | | | | xxCxxxxxxxxxxxxxxxxCCxxCxxxxCxxxxxCCxxxCxxxxxxxxxCxxxxxxxxxxxxxxCCxxxxCxxxx | | | | | | +-----------------+ +------+ +---------------+ C = cysteine, x = any amino acid
Serum albumin is the most abundant blood plasma protein and is produced in the liver and forms a large proportion of all plasma protein. The human version is human serum albumin, and it normally constitutes about 60% of human plasma protein.
Serum albumins are important in regulating blood volume by maintaining the oncotic pressure (also known as colloid osmotic pressure) of the blood compartment. They also serve as carriers for molecules of low water solubility this way isolating their hydrophobic nature, including lipid soluble hormones, bile salts, unconjugated bilirubin, free fatty acids (apoprotein), calcium, ions (transferrin), and some drugs like warfarin, phenobutazone, clofibrate & phenytoin. For this reason, it's sometimes referred as a molecular "taxi". Competition between drugs for albumin binding sites may cause drug interaction by increasing the free fraction of one of the drugs, thereby affecting potency.
Specific types include:
Low albumin (hypoalbuminemia) may be caused by liver disease, nephrotic syndrome, burns, protein-losing enteropathy, malabsorption, malnutrition, late pregnancy, artefact, genetic variations and malignancy.
High albumin (hyperalbuminemia) is almost always caused by dehydration. In some cases of retinol (Vitamin A) deficiency the albumin level can be elevated to high-normal values (e.g., 4.9 g/dL). This is because retinol causes cells to swell with water (this is also the reason too much Vitamin A is toxic).[9] In lab experiments it has been shown that All-trans retinoic acid down regulates human albumin production[10]
Normal range of human serum albumin in adults (> 3 y.o.) is 3.5 to 5 g/dL. For children less than three years of age, the normal range is broader, 2.9-5.5 g/dL.[11]
Albumin binds to the cell surface receptor Albondin.
Other types include the storage protein ovalbumin in egg white, and different storage albumins in the seeds of some plants.
Wikisource has the text of the 1911 Encyclopædia Britannica article Albumin. |
This article incorporates text from the public domain Pfam and InterPro IPR014760
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