CSPG4
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Chondroitin sulfate proteoglycan 4 | |||
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Identifiers | |||
Symbols | CSPG4; MSK16; HMW-MAA; MCSP; MCSPG; MEL-CSPG; NG2 | ||
External IDs | OMIM: 601172 MGI: 2153093 HomoloGene: 20445 GeneCards: CSPG4 Gene | ||
RNA expression pattern | |||
More reference expression data | |||
Orthologs | |||
Species | Human | Mouse | |
Entrez | 1464 | 121021 | |
Ensembl | ENSG00000173546 | ENSMUSG00000032911 | |
UniProt | Q6UVK1 | Q09J74 | |
RefSeq (mRNA) | NM_001897 | NM_139001 | |
RefSeq (protein) | NP_001888 | NP_620570 | |
Location (UCSC) | Chr 15: 73.75 - 73.79 Mb | Chr 9: 56.66 - 56.7 Mb | |
PubMed search | [1] | [2] |
Chondroitin sulfate proteoglycan 4 or melanoma-associated chondroitin sulfate proteoglycan (MCSP) is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene.[1][2][3]
CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.[3]
References
- ^ Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA (Oct 1996). [Expression error: Missing operand for > "Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan"]. Proc Natl Acad Sci U S A 93 (18): 9710-5. PMID 8790396.
- ^ Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S (May 2006). [Expression error: Missing operand for > "Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells"]. Oncogene 25 (20): 2873-84. doi: . PMID 16407841.
- ^ a b "Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1464.
Further reading
- Kirschfink M, Blase L, Engelmann S, Schwartz-Albiez R (1997). [Expression error: Missing operand for > "Secreted chondroitin sulfate proteoglycan of human B cell lines binds to the complement protein C1q and inhibits complex formation of C1."]. J. Immunol. 158 (3): 1324–31. PMID 9013976.
- Iida J, Meijne AM, Oegema TR, et al. (1998). [Expression error: Missing operand for > "A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion."]. J. Biol. Chem. 273 (10): 5955–62. doi: . PMID 9488735.
- Eisenmann KM, McCarthy JB, Simpson MA, et al. (2000). [Expression error: Missing operand for > "Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas."]. Nat. Cell Biol. 1 (8): 507–13. doi: . PMID 10587647.
- Barritt DS, Pearn MT, Zisch AH, et al. (2000). [Expression error: Missing operand for > "The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2."]. J. Cell. Biochem. 79 (2): 213–24. doi: . PMID 10967549.
- Iida J, Pei D, Kang T, et al. (2001). [Expression error: Missing operand for > "Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen."]. J. Biol. Chem. 276 (22): 18786–94. doi: . PMID 11278606.
- Staub E, Hinzmann B, Rosenthal A (2002). [Expression error: Missing operand for > "A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family."]. FEBS Lett. 527 (1-3): 114–8. doi: . PMID 12220645.
- Stegmüller J, Werner H, Nave KA, Trotter J (2003). [Expression error: Missing operand for > "The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling."]. J. Biol. Chem. 278 (6): 3590–8. doi: . PMID 12458226.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: . PMID 12477932.
- Legg J, Jensen UB, Broad S, et al. (2004). [Expression error: Missing operand for > "Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis."]. Development 130 (24): 6049–63. doi: . PMID 14573520.
- Ghali L, Wong ST, Tidman N, et al. (2004). [Expression error: Missing operand for > "Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein."]. J. Invest. Dermatol. 122 (2): 433–42. doi: . PMID 15009727.
- Fukushi J, Makagiansar IT, Stallcup WB (2005). [Expression error: Missing operand for > "NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin."]. Mol. Biol. Cell 15 (8): 3580–90. doi: . PMID 15181153.
- Yang J, Price MA, Neudauer CL, et al. (2004). [Expression error: Missing operand for > "Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms."]. J. Cell Biol. 165 (6): 881–91. doi: . PMID 15210734.
- Colland F, Jacq X, Trouplin V, et al. (2004). [Expression error: Missing operand for > "Functional proteomics mapping of a human signaling pathway."]. Genome Res. 14 (7): 1324–32. doi: . PMID 15231748.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). [Expression error: Missing operand for > "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions."]. Genome Res. 14 (9): 1711–8. doi: . PMID 15342556.
- Makagiansar IT, Williams S, Dahlin-Huppe K, et al. (2005). [Expression error: Missing operand for > "Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility."]. J. Biol. Chem. 279 (53): 55262–70. doi: . PMID 15504744.
- Petrini S, Tessa A, Stallcup WB, et al. (2006). [Expression error: Missing operand for > "Altered expression of the MCSP/NG2 chondroitin sulfate proteoglycan in collagen VI deficiency."]. Mol. Cell. Neurosci. 30 (3): 408–17. doi: . PMID 16169245.
- Brekke C, Lundervold A, Enger PØ, et al. (2006). [Expression error: Missing operand for > "NG2 expression regulates vascular morphology and function in human brain tumours."]. Neuroimage 29 (3): 965–76. doi: . PMID 16253523.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). [Expression error: Missing operand for > "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."]. J. Proteome Res. 4 (6): 2070–80. doi: . PMID 16335952.
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