Inosine monophosphate synthase
From Wikipedia
| edit |
| 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | |||
|---|---|---|---|
PDB rendering based on 1p4r. | |||
| Available structures | |||
| 1p4r, 1pkx, 1pl0 | |||
| Identifiers | |||
| Symbols | ATIC; AICAR; AICARFT; IMPCHASE; PURH | ||
| External IDs | OMIM: 601731 MGI: 1351352 HomoloGene: 2983 GeneCards: ATIC Gene | ||
| RNA expression pattern | |||
| More reference expression data | |||
| Orthologs | |||
| Species | Human | Mouse | |
| Entrez | 471 | 108147 | |
| Ensembl | ENSG00000138363 | ENSMUSG00000026192 | |
| UniProt | P31939 | Q3UTQ3 | |
| RefSeq (mRNA) | NM_004044 | XM_987290 | |
| RefSeq (protein) | NP_004035 | XP_992384 | |
| Location (UCSC) | Chr 2: 215.89 - 215.92 Mb | Chr 1: 71.49 - 71.51 Mb | |
| PubMed search | [1] | [2] | |
Bifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene.[1][2][3]
ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide.
It has two functions:
- EC 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
- EC 3.5.4.10 - IMP cyclohydrolase
References
- ↑ Rayl EA, Moroson BA, Beardsley GP (Mar 1996). [Expression error: Missing operand for > "The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping"]. J Biol Chem 271 (4): 2225-33. PMID 8567683.
- ↑ Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (Nov 1997). [Expression error: Missing operand for > "Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase"]. J Biochem 122 (2): 309-13. PMID 9378707.
- ↑ "Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=471.
Further reading
- Rasmussen HH, van Damme J, Puype M, et al. (1993). [Expression error: Missing operand for > "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."]. Electrophoresis 13 (12): 960–9. doi:. PMID 1286667.
- Yamauchi M, Seki N, Mita K, et al. (1996). [Expression error: Missing operand for > "Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript."]. DNA Res. 2 (6): 269–75. doi:. PMID 8867801.
- Beardsley GP, Rayl EA, Gunn K, et al. (1998). [Expression error: Missing operand for > "Structure and functional relationships in human pur H."]. Adv. Exp. Med. Biol. 431: 221–6. PMID 9598063.
- Vergis JM, Bulock KG, Fleming KG, Beardsley GP (2001). [Expression error: Missing operand for > "Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity."]. J. Biol. Chem. 276 (11): 7727–33. doi:. PMID 11096114.
- Bulock KG, Beardsley GP, Anderson KS (2002). [Expression error: Missing operand for > "The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling."]. J. Biol. Chem. 277 (25): 22168–74. doi:. PMID 11948179.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Cheong CG, Wolan DW, Greasley SE, et al. (2004). [Expression error: Missing operand for > "Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates."]. J. Biol. Chem. 279 (17): 18034–45. doi:. PMID 14966129.
- Marie S, Heron B, Bitoun P, et al. (2004). [Expression error: Missing operand for > "AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC."]. Am. J. Hum. Genet. 74 (6): 1276–81. doi:. PMID 15114530.
- Dervieux T, Furst D, Lein DO, et al. (2004). [Expression error: Missing operand for > "Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis."]. Arthritis Rheum. 50 (9): 2766–74. doi:. PMID 15457444.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). [Expression error: Missing operand for > "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."]. Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
- Ewing RM, Chu P, Elisma F, et al. (2007). [Expression error: Missing operand for > "Large-scale mapping of human protein-protein interactions by mass spectrometry."]. Mol. Syst. Biol. 3: 89. doi:. PMID 17353931.
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