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⇨ Alkaline Phosphodiesterase • Alkaline Phosphodiesterase I • CAMP Phosphodiesterase • Ca-CaM-Phosphodiesterase • Calmodulin Phosphodiesterase • Cyclic AMP-Phosphodiesterase Activator • PDE2 Phosphodiesterase • PDE4D3 Phosphodiesterase • PPI Phosphodiesterase • Phosphodiesterase 1A, Calmodulin-Dependent • Phosphodiesterase 1B, Calmodulin-Dependent • Phosphodiesterase 1C, Calmodulin-Dependent • Phosphodiesterase 2A • Phosphodiesterase 3A • Phosphodiesterase 3B • Phosphodiesterase 4 • Phosphodiesterase 4A • Phosphodiesterase 4B • Phosphodiesterase 4C • Phosphodiesterase 4D • Phosphodiesterase 5 • Phosphodiesterase 6 • Phosphodiesterase Activating Factor • Phosphodiesterase Activator Protein • Phosphodiesterase Antagonists • Phosphodiesterase I • Phosphodiesterase III • Phosphodiesterase IV • Phosphodiesterase Inhibitors • Phosphodiesterase Protein Activator • Phosphodiesterase Type 6 • Phosphodiesterase V • Phosphodiesterase-4 • Phosphodiesterase-5 • Phosphodiesterase-7 • Retinal Phosphodiesterase 6 • Retinal Phosphodiesterase, alpha Subunit • Retinal Phosphodiesterase, beta Subunit • Retinal Phosphodiesterase, delta Subunit • Rod cGMP Phosphodiesterase, beta Subunit • cAMP Phosphodiesterase-7 • cGMP Phosphodiesterase delta Subunit
⇨ (acyl-carrier-protein) phosphodiesterase • 2',3'-cyclic-nucleotide 2'-phosphodiesterase • 2',3'-cyclic-nucleotide 3'-phosphodiesterase • 2’,3’-Cyclic Nucleotide 3’-Phosphodiesterase • 3',5'-cyclic-GMP phosphodiesterase • Alkylglycerophosphoethanolamine phosphodiesterase • CGMP-specific phosphodiesterase type 5 • CMP-N-acylneuraminate phosphodiesterase • Dolichylphosphate-glucose phosphodiesterase • Dolichylphosphate-mannose phosphodiesterase • Ectonucleotide pyrophosphatase/phosphodiesterase 1 • GMP phosphodiesterase, delta subunit • Glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase • Glycerol-1,2-cyclic-phosphate 2-phosphodiesterase • Glycerophosphocholine phosphodiesterase • Glycerophosphodiester phosphodiesterase • Phosphodiesterase inhibitor • Serine-ethanolaminephosphate phosphodiesterase • Sphingomyelin phosphodiesterase • Sphingomyelin phosphodiesterase 1
Wikipedia
A phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.
The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.
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These multiple forms (isoforms or subtypes) of phosphodiesterase were isolated from rat brain using polyacrylamide gel electrophoresis in the early 1970s[1][2] and were soon afterward shown to be selectively inhibited by a variety of drugs in brain and other tissues.[3][4]
The potential for selective phosphodiesterase inhibitors to be used as therapeutic agents was predicted as early as 1977 by Weiss and Hait.[5] This prediction has now come to pass in a variety of fields (e.g. Viagra as a PDE5 inhibitor and Diazepam as a PDE4 inhibitor ).
The PDE superfamily of enzymes is classified into 11 families, namely PDE1-PDE11, in mammals. The classification is based on:
Different PDEs of the same family are functionally related despite the fact that their amino acid sequences can show considerable divergence.[6] PDEs have different substrate specificities. Some are cAMP-selective hydrolases (PDE4, 7 and 8); others are cGMP-selective (PDE5, 6, and 9). Others can hydrolyse both cAMP and cGMP (PDE1, 2, 3, 10, and 11). PDE3 is sometimes referred to as cGMP-inhibited phosphodiesterase. Although PDE2 can hydrolyze both cyclic nucleotides, binding of cGMP to the regulatory GAF-B domain will increase cAMP affinity and hydrolysis to the detriment of cGMP. This mechanism, as well as others, allows for cross-regulation of the cAMP and cGMP pathways.
The nomenclature for PDE indicates PDE family by an Arabic numeral that is followed by a capital letter to denote the gene within a family. A second Arabic numeral indicates the splice variant derived from a single gene (e.g., PDE1C3: family 1, gene C, splicing variant 3)[7]
Phosphodiesterase enzymes are often targets for pharmacological inhibition due to their unique tissue distribution, structural properties, and functional properties.[8]
Inhibitors of PDE can prolong or enhance the effects of physiological processes mediated by cAMP or cGMP by inhibition of their degradation by PDE.
Sildenafil (Viagra) is an inhibitor of cGMP-specific phosphodiesterase type 5, which enhances the vasodilatory effects of cGMP in the corpus cavernosum and is used to treat erectile dysfunction. Sildenafil is also currently being investigated for its myo- and cardioprotective effects, with particular interest being given to the compound's therapeutic value in the treatment of Duchenne muscular dystrophy [9] and benign prostatic hyperplasia.[10]
PDE inhibitors have been identified as new potential therapeutics in areas such as pulmonary arterial hypertension, coronary heart disease, dementia, depression, and schizophrenia.
Cilostazol (Pletal) inhibits PDE3. This inhibition allows red blood cells to be more able to bend. This is useful in conditions such as intermittent claudication, as the cells can maneuver through constricted veins and arteries more easily.
Xanthines, caffeine, theobromine, and thyroid hormone are phosphodiesterase inhibitors (enhance lipolysis as inhibition of phosphodiesterase enzyme, thereby preserving cAMP, also activating kinase enzyme, which phosphorylates hormone-sensitive lipase and activates lipolysis).
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