SERPINI2
From Wikipedia, the free encyclopedia
| edit |
| Serpin peptidase inhibitor, clade I (pancpin), member 2 | |||||||||
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| Identifiers | |||||||||
| Symbols | SERPINI2; MEPI; PANCPIN; PI14; TSA2004 | ||||||||
| External IDs | OMIM: 605587 MGI: 1915181 HomoloGene: 21248 GeneCards: SERPINI2 Gene | ||||||||
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| RNA expression pattern | |||||||||
| More reference expression data | |||||||||
| Orthologs | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | 5276 | 67931 | |||||||
| Ensembl | ENSG00000114204 | ENSMUSG00000034139 | |||||||
| UniProt | O75830 | Q4G0D3 | |||||||
| RefSeq (mRNA) | NM_006217 | NM_026460 | |||||||
| RefSeq (protein) | NP_006208 | NP_080736 | |||||||
| Location (UCSC) | Chr 3: 168.64 - 168.67 Mb | Chr 3: 75.33 - 75.36 Mb | |||||||
| PubMed search | [1] | [2] | |||||||
Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene.[1][2]
The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.[2]
References
- ^ Ozaki K, Nagata M, Suzuki M, Fujiwara T, Miyoshi Y, Ishikawa O, Ohigashi H, Imaoka S, Takahashi E, Nakamura Y (Jul 1998). [Expression error: Missing operand for > "Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells"]. Genes Chromosomes Cancer 22 (3): 179-85. PMID 9624529.
- ^ a b "Entrez Gene: SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5276.
Further reading
- Maruyama K, Sugano S (1994). [Expression error: Missing operand for > "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides."]. Gene 138 (1-2): 171–4. doi:. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). [Expression error: Missing operand for > "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library."]. Gene 200 (1-2): 149–56. doi:. PMID 9373149.
- Xiao G, Liu YE, Gentz R, et al. (1999). [Expression error: Missing operand for > "Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells."]. Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3700–5. doi:. PMID 10097100.
- Chang WS, Chang NT, Lin SC, et al. (2000). [Expression error: Missing operand for > "Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26."]. Genes Chromosomes Cancer 29 (3): 240–55. doi:. PMID 10992299.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). [Expression error: Missing operand for > "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."]. Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). [Expression error: Missing operand for > "Towards a proteome-scale map of the human protein-protein interaction network."]. Nature 437 (7062): 1173–8. doi:. PMID 16189514.
- Lim J, Hao T, Shaw C, et al. (2006). [Expression error: Missing operand for > "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration."]. Cell 125 (4): 801–14. doi:. PMID 16713569.
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