Syndecan 1
From Wikipedia
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| Syndecan 1 | |||||||||
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| Identifiers | |||||||||
| Symbols | SDC1; CD138; SDC; SYND1; syndecan | ||||||||
| External IDs | OMIM: 186355 MGI: 1349162 HomoloGene: 2252 GeneCards: SDC1 Gene | ||||||||
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| RNA expression pattern | |||||||||
| More reference expression data | |||||||||
| Orthologs | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | 6382 | 20969 | |||||||
| Ensembl | ENSG00000115884 | ENSMUSG00000020592 | |||||||
| UniProt | P18827 | Q3THY2 | |||||||
| RefSeq (mRNA) | NM_001006946 | NM_011519 | |||||||
| RefSeq (protein) | NP_001006947 | NP_035649 | |||||||
| Location (UCSC) | Chr 2: 20.26 - 20.29 Mb | Chr 12: 8.8 - 8.82 Mb | |||||||
| PubMed search | [1] | [2] | |||||||
Syndecan 1 is a protein which in humans is encoded by the SDC1 gene.[1][2]
Contents |
Function
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.[3]
Application
It is a useful marker for plasma cells,[4] but only if the cells tested are already known to be derived from blood.[5]
References
- ↑ Mali M, Jaakkola P, Arvilommi AM, Jalkanen M (April 1990). "Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans". J. Biol. Chem. 265 (12): 6884–9. ISSN . PMID 2324102. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=2324102.
- ↑ Ala-Kapee M, Nevanlinna H, Mali M, Jalkanen M, Schröder J (September 1990). [Expression error: Missing operand for > "Localization of gene for human syndecan, an integral membrane proteoglycan and a matrix receptor, to chromosome 2"]. Somat. Cell Mol. Genet. 16 (5): 501–5. doi:. PMID 2173154.
- ↑ "Entrez Gene: SDC1 syndecan 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6382.
- ↑ Rawstron AC (May 2006). [Expression error: Missing operand for > "Immunophenotyping of plasma cells"]. Curr Protoc Cytom Chapter 6: Unit6.23. doi:. PMID 18770841.
- ↑ O'Connell FP, Pinkus JL, Pinkus GS (February 2004). "CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms". Am. J. Clin. Pathol. 121 (2): 254–63. doi:. PMID 14983940. http://ajcp.metapress.com/openurl.asp?genre=article&issn=0002-9173&volume=121&issue=2&spage=254.
Further reading
- David G (1992). [Expression error: Missing operand for > "Structural and functional diversity of the heparan sulfate proteoglycans"]. Adv. Exp. Med. Biol. 313: 69–78. PMID 1442271.
- Jaakkola P, Jalkanen M (1999). [Expression error: Missing operand for > "Transcriptional regulation of Syndecan-1 expression by growth factors"]. Prog. Nucleic Acid Res. Mol. Biol. 63: 109–38. doi:. PMID 10506830.
- Wijdenes J, Dore JM, Clement C, Vermot-Desroches C (2003). [Expression error: Missing operand for > "CD138"]. J. Biol. Regul. Homeost. Agents 16 (2): 152–5. PMID 12144130.
- Lories V, Cassiman JJ, Van den Berghe H, David G (1992). [Expression error: Missing operand for > "Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts"]. J. Biol. Chem. 267 (2): 1116–22. PMID 1339431.
- Vainio S, Jalkanen M, Bernfield M, Saxén L (1992). [Expression error: Missing operand for > "Transient expression of syndecan in mesenchymal cell aggregates of the embryonic kidney"]. Dev. Biol. 152 (2): 221–32. doi:. PMID 1644217.
- Kiefer MC, Ishihara M, Swiedler SJ, et al. (1992). [Expression error: Missing operand for > "The molecular biology of heparan sulfate fibroblast growth factor receptors"]. Ann. N. Y. Acad. Sci. 638: 167–76. doi:. PMID 1664683.
- Ala-Kapee M, Nevanlinna H, Mali M, et al. (1990). [Expression error: Missing operand for > "Localization of gene for human syndecan, an integral membrane proteoglycan and a matrix receptor, to chromosome 2"]. Somat. Cell Mol. Genet. 16 (5): 501–5. doi:. PMID 2173154.
- Mali M, Jaakkola P, Arvilommi AM, Jalkanen M (1990). [Expression error: Missing operand for > "Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans"]. J. Biol. Chem. 265 (12): 6884–9. PMID 2324102.
- Sanderson RD, Lalor P, Bernfield M (1992). [Expression error: Missing operand for > "B lymphocytes express and lose syndecan at specific stages of differentiation"]. Cell Regul. 1 (1): 27–35. PMID 2519615.
- Asundi VK, Carey DJ (1995). [Expression error: Missing operand for > "Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region"]. J. Biol. Chem. 270 (44): 26404–10. doi:. PMID 7592855.
- Zhang L, David G, Esko JD (1995). [Expression error: Missing operand for > "Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans"]. J. Biol. Chem. 270 (45): 27127–35. doi:. PMID 7592967.
- Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). [Expression error: Missing operand for > "The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence"]. Proc. Natl. Acad. Sci. U.S.A. 90 (17): 7941–5. doi:. PMID 7690138.
- Spring J, Goldberger OA, Jenkins NA, et al. (1994). [Expression error: Missing operand for > "Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family"]. Genomics 21 (3): 597–601. doi:. PMID 7959737.
- Sneed TB, Stanley DJ, Young LA, Sanderson RD (1994). [Expression error: Missing operand for > "Interleukin-6 regulates expression of the syndecan-1 proteoglycan on B lymphoid cells"]. Cell. Immunol. 153 (2): 456–67. doi:. PMID 8118875.
- Maruyama K, Sugano S (1994). [Expression error: Missing operand for > "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides"]. Gene 138 (1-2): 171–4. doi:. PMID 8125298.
- Kokenyesi R, Bernfield M (1994). [Expression error: Missing operand for > "Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1"]. J. Biol. Chem. 269 (16): 12304–9. PMID 8163535.
- Albini A, Benelli R, Presta M, et al. (1996). [Expression error: Missing operand for > "HIV-tat protein is a heparin-binding angiogenic growth factor"]. Oncogene 12 (2): 289–97. PMID 8570206.
- Bonaldo MF, Lennon G, Soares MB (1997). [Expression error: Missing operand for > "Normalization and subtraction: two approaches to facilitate gene discovery"]. Genome Res. 6 (9): 791–806. doi:. PMID 8889548.
- Kaukonen J, Alanen-Kurki L, Jalkanen M, Palotie A (1997). [Expression error: Missing operand for > "The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p"]. Hum. Genet. 99 (3): 295–7. doi:. PMID 9050911.
External links
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